Bremelanotide PT-141 Reviews And Warnnings

Bremelanotide ( PT – 141), began development in 2004 and is still undergoing trials. Bremelanotide is a peptide melanocortin receptor antagonist which is under current development by Palatin Technologies as the treatment for sexual dysfunction. It is made from the peptide Melanotan II, which underwent testing as a sunless tanning agent. In initial testing, it was ineffective as a tanning agent, however, it unexpectedly produced sexual arousal.

Benefits & effect

PT 141 works by stimulating melanocortin receptors in the brain. It can be injected under the skin or inhaled through the nose as a treatment for sexual dysfunction. It is known for taking effect quickly, usually in less than one hour. There are many benefits that this peptide has to offer for men and women struggling with decreased sexual desire and ability.

Treating erectile dysfunction

Erectile dysfunction (ED) can be caused by many factors, including medical conditions, mental illness, or certain medications. There are many types of treatment for ED, but some can cause serious side effects.

PT 141 causes your brain to release nitric oxide, which relaxes the muscles of the penis and increases blood flow to the region.

This increase in blood flow can help men with ED achieve an erection.

Increased sexual desire

One thing that makes PT 141 stand out is that it can be used for both men and women. It has been found to improve sexual desire in premenopausal women diagnosed with sexual arousal disorder.
woman looking seductively at the camera

Other benefits of PT 141

Because it also leads to increased desire rather than just increased blood flow to the sex organs, PT 141 also leads to improved sexual performance and has the potential for improved mood and general well-being. This is because people perform better sexually when there is increased desire rather than just increased blood flow alone, as with other types of medications.

side effect

Like any other medication, PT 141 can cause side effects. The most commonly reported side effects are:

• Flushing
• Headaches
• Nausea
• Skin irritation

Flushing

Flushing is characterized by redness or a feeling of warmth or tingling in the skin. It occurs when the blood vessels in your skin become dilated. Mild to moderate flushing is common with PT 141 use but can be more severe for some people.

Headaches

PT 141 can also cause head pain and pressure, but this side effect is usually mild to moderate in severity and should go away on its own after a few hours.

Nausea

Although uncomfortable, queasiness is another common mild to moderate side effect that should resolve itself over time.
woman having a headache and holding her head

Skin irritation

It is likely that you may experience mild to moderate itching, redness, or pain at the injection site after taking PT 141. Like other common side effects, any skin irritation should go away on its own.

Less common side effects

The severity and duration of side effects can vary by individual. Contact your doctor immediately if you experience any of the following serious side effects of PT 141:

• Blurred vision
• Darkening of the face
• Darkening of the gums
• Dizziness
• Fatigue
• Joint pain
• Joint swelling
• Runny nose
• Stuffy nose
• Vomiting

Other issues

Taking PT 141 can also increase your risk for blood pressure spikes, potentially impacting other medical conditions, such as heart disease.

Risks of PT 141

Although PT 141 shows promise in effectively treating sexual dysfunction in men and women, more research is needed to better understand its long-term effects. There are both known and unknown risks associated with PT 141.

Unknown long-term effects

The long-term effects of PT 141 have not yet been widely studied. This means that experts are uncertain about the safety of taking PT 141 over an extended period, especially for individuals with other health conditions. It is also unknown if PT 141 becomes less effective over long periods.

A 52-week study monitored PT 141 use in premenopausal women with hypoactive sexual desire disorder and found that the treatment remained effective for the duration of the study.

Potential for abuse or misuse

The potential for the abuse or misuse of a drug increases if its effectiveness decreases over time. With most drugs, the body develops a tolerance over time, so a higher dose is needed to achieve the same results. This can lead patients to take more medication than prescribed, which can be dangerous.
yellow pills on a blue background
Possible impact on hormone levels and fertility

More research is needed on the effects of PT 141 on hormone levels and fertility.

How Do I Take PT-141?

The easy subcutaneous self-injection of PT-141 is made just underneath your skin, and is only given once every 72 or more hours. I often recommend that men or women dose with the medication once or twice per week, as needed, to enjoy having their desired libido and sexual function. It usually takes anywhere from 2 – 4 hours to take effect. Under the direct care of a physician your PT-141 dose will be titrated to meet your exact needs. The fact that you only need one injection every 72 or more hours allows for spontaneity. Many of my patients who use oral medication for erectile dysfunction often comment on the fact that they have to take a pill and “wait” for it to take effect, sometimes to the chagrin of their sexual partner. With a every 72 hours or so dosing schedule PT-141 does not get in the way of spontaneity.

Content and Potency: 10mg/mL x 2 mL vials ready-to-inject subcutaneous
Suggested dosage: Inject 0.2ml when required 4 hours prior to activity (Duration 6-8 hours).

Conclusion

PT 141 is a synthetic peptide that stimulates the brain’s melanocortin receptors and causes the brain to release nitric oxide. It can be used to treat sexual desire disorder in women and erectile dysfunction in men by increasing sexual desire and blood flow to the sex organs. It can also help improve sexual performance and elevate mood.

Pros of PT 141 include:

• Increased sexual desire
• Increased sexual arousal
• Improved sexual function
• Improved sexual performance
• May lead to improved mood
• May lead to better overall well-being

Cons of PT 141 include:

• Potential mild to moderate side effects
• Possible impact on certain medical conditions such as heart disease
• Increased risks for spikes in blood pressure

Due to the cons and risks outlined above, along with the lack of long-term safety data about PT 141, it is important that you discuss PT 141 with your doctor before deciding to take it. This is especially important if you have other health conditions like heart disease or high blood pressure. Your doctor will be able to assess the risks and benefits of taking PT 141, and you can work together to determine whether it may be right for you.

Contact a healthcare provider immediately if you notice any of the less common side effects of PT 141 listed in this article or if a common side effect does not resolve in a timely manner on its own.

Reviews

You May Want To Know More

Aging Often Causes Decreased Libido and Sexual Function:

There are many facets of the aging process. Changes in energy, mental function, and deterioration of body composition are some of the top concerns of people when they are aging. Perhaps the least talked about and most troublesome aspect of aging for both men as well as for women is sexual function, including libido – which means “sexual desire” – and is definitely an important part of sexual function.

Circulating levels of testosterone and estrogen decline as we age, and as a result our libido and sexual function tend to drop as well. As usual the first step with dealing with any negative aspects of aging is to address dietary and lifestyle factors that are contributing to the decline. Eliminating processed foods and sticking to a majority whole food plant based diet should be your foundation. A secondary aspect would be to balance your hormones. Making an appointment with a licensed physician who specializes in testosterone replacement therapy and hormone replacement therapy who can evaluate and correct hormone deficiencies or imbalances would be the next step.

Often Oral Medications Don’t Work Because There’s Not Enough Libido:

Even after taking care of the aforementioned steps, some patients still struggle with sexual desire and performance. Oftentimes, guys turn to one of the common oral medications for erectile dysfunction (Viagra®, Cialis®, or Levitra®). Although these medications can be very effective and a life-saver for some patients, they are not without side-effects. Some patients shy away from these medications, because they do not want to deal with the common issues of headache, congestion, and in some cases muscle aches, or other adverse effects In addition, these oral medications do not address the issue of sexual desire that is often in decline as we age. And these medications will not work if there is no sexual desire.

How Does PT-141 Work to Improve Libido and Sexual Function?

PT-141 also known as bremelanotide is a compounded injectable prescription that can be used to improve libido. By improving libido it has been shown to increase physical arousal and genital circulation, therefore to increase the filling and function of erectile and other genital tissue in men and women. There is a strong connection between sexual arousal and the ability to perform sexually. This medication targets both. Unlike common oral medications like Viagra®, Cialis®, or Levitra®, PT- 141 acts directly on the nervous system to stimulate arousal. By doing so it eliminates the chances of priapism, (a prolonged and often uncomfortable erection) headache and congestion when dosed properly. In addition PT-141 may stimulate dopamine release. Dopamine is typically thought of as a chemical of pleasure, but more recently it has been associated with motivational salience. In other words the desire to do an act based on the perceived level of satisfaction or outcome.

Does PT-141 Work for Women?

Another exciting feature of this medication is that it is effective for women as well. Many women suffer from hypoactive sexual desire disorder (HSDD). This is characterized by a lack or absence of sexual fantasies or desire for sexual activity in the absence of a diagnosed psychological disorder or a bad relationship. PT- 141 has proven to be effective for women. A 2016 study found that taking PT- 141 over 12 weeks increased the number of sexually satisfying events (SSE) in pre-menopausal women who suffered from hypoactive sexual arousal disorder (HSDD) and female sexual arousal disorder (FSAD). Participants also had an increase in their female sexual function index (FSFI) and orgasm score total with no adverse effects.

Case Studies inPrescribing PT-141 to Improve Libido and Sexual Function:

The first patient that I treated with this medication was a 54 year-old male with no acute or chronic medical diagnosis. He was recently divorced and was looking to start dating again. He expressed fear about being intimate with a woman since his last two sexual experiences were less than ideal for him. In particular, he was struggling with his ability to maintain an erection, and as a result he had developed less and less interest in sex over time. After being prescribed PT-141 he reported back with extreme satisfaction and enthusiasm. He reported that he was not only able to maintain an erection, but his erections were more full and firm. In addition he reported a very short refractory period after ejaculation. He was “ready to go” again very soon after. He has been using it for the past several months with no adverse effects.

Another case was with a 33 year-old female who was recently married and was self-described as “sexless”. After carefully titrating her dose of PT- 141 she reports an active sex life. A few months later she made an appointment for her husband who now also uses PT-141.